Thursday, 18.05.2023

17:30	Registration
18:00	Opening
18:30	Kim Stegmaier (keynote speaker): Ewing Sarcoma – A Goldilocks Tale
19:30	Welcome reception

Friday, 19.05.2023

SESSION 1

08:30	Registration
09:00	Isidro Cortes-Ciriano (guest speaker): Malignant peripheral nerve sheath tumour (MPNST) evolution is defined by recurrent copy number aberrations that are detectable in cell-free DNA and predict clinical outcome
09:30	Beate Rinner: Patient-derived translocation-related sarcoma models enables translational research and tailored therapies
09:45	Nikolaus Mandlburger: Potentials of epigenetic analysis of cell-free DNA for liquid biopsies in Ewing sarcoma
10:00	Natacha Entz-Werlé: Osteoblastic-gene signature to predict survival in pediatric osteosarcoma (OS) and to follow patients towards liquid biopsy: a collaborative work in OS2006 protocol.
10:15	Flash Talks
10:45	Coffee Break

SESSION 2

11:15	Anna Obenauf (guest speaker): Towards rational combination therapies: Understanding tumor evolution during therapy response and resistance
11:45	Marie Castets: Targeting cell death in rhabdomyosarcoma: new perspectives from organoid technology.
12:00	Martin Distel: cPLA2 expression correlates with enhanced invasion of osteosarcoma cells in vivo
12:15	Birgit Lohberger: Cellular and molecular biological alterations after proton and carbon ion irradiation in human chondrosarcoma cells with respect to DNA repair and radiosensitivity
12:30	Flash Talks
13:00	Lunch Break

SESSION 3

14:00	Silvia Stacchiotti (guest speaker): New treatments for ultra-rare sarcomas
14:30	Sofia Avnet: Gut microbiota dynamics in osteosarcoma patients undergoing chemotherapy treatment and its association with response to therapy
14:45	Sara Sánchez Molina: KDM6 demethylases mediate EWSR1-FLI1-driven oncogenic transformation in Ewing Sarcoma
15:00	Aykut Uren: Piperacetazine directly binds to PAX3::FOXO1 and inhibits its transcriptional activity in rhabdomyosarcoma cells
15:15	Flash Talks
15:45	Coffee Break

SESSION 4

16:15	Florian Grebien (guest speaker): Oncogenic mechanisms of fusion proteins in pediatric cancer
16:45	Sibylle Mittnacht: Therapeutics profiling identifies selective vulnerabilities in standard-of-care agent unresponsive osteosarcoma
17:00	Christoph Hafemeister: Tracking Ewing Sarcoma origin using Developmental Genomics
17:15	Julian Musa: Chromosome 8 gain drives poor patient outcome via expression of 4E-BP1 in Ewing sarcoma
17:30	Flash Talks
19:30	Social Event

Saturday, 20.05.2023

SESSION 5

08:30	Registration
09:00	Georg Winter (guest speaker): Targeting gene control in cancer via small-molecule degraders
09:30	Ian Lock: Identifying non-canonical p53 functions that mediate tumor suppression
09:45	Javier Munoz-Garcia: ETV4 controls the dormancy of osteosarcoma cells
10:00	Kazuhiko Matsuoka: Activation of c-Fos and p53 inactivation drives recurrent/metastatic Osteosarcoma
10:15	Flash Talks
10:45	Coffee Break

SESSION 6

11:00	Christoph Bock (guest speaker): Programmed Cells? Machine learning for precision medicine
11:30	Antonin Marchais: Deciphering the Spatial Complexity of Osteosarcoma Lung Metastases: Unveiling Metaphyseal-Like Tumor Architecture and Recurrent Immunosuppression
11:45	Nezha Benabdallah: An autoregulatory feedback loop converging on H2A ubiquitination drives synovial sarcoma
12:00	Closing Remarks
12:15	End