National & International Grants
Nationally Funded Projects
HSP90IES – New Hsp90 Inhibitor-based Therapies for Ewing Sarcoma
CCRI responsible Head of Facility and Coordinator: Martin Distel
Grant from the Austrian Science Fund (FWF), Principal Investigator Project International, DOI: 10.55776/I6685
Duration: TBD (Grant Agreement under preparation)
https://www.fwf.ac.at/en/research-radar/10.55776/I6685
HIPSC-LCH – Human Induced Pluripotent Stem Cells as a preclinical trial platform for Langerhans Cell Histiocytosis
CCRI responsible Principal Investigator: Caroline Hutter
Grant from the Austrian Science Fund (FWF), Principal Investigator Project, DOI: 10.55776/P37332
Duration: TBD (Grant Agreement under preparation)
https://www.fwf.ac.at/en/research-radar/10.55776/P37332
Oncogenic aberration of development in childhood cancer
CCRI responsible Principal Investigator: Florian Halbritter
Grant from the Austrian Science Fund (FWF), Principal Investigator Project, DOI: 10.55776/PAT1300223
Duration: TBD (Grant Agreement under preparation)
https://www.fwf.ac.at/en/research-radar/10.55776/PAT1300223
PROMISE – Proteostasis, Metabolism and a Novel Immunodeficiency Syndrome
CCRI responsible Project Lead: Michael Kraakman (Kaan Boztug group)
Grant from the Austrian Science Fund (FWF), Principal Investigator Project, DOI: 10.55776/PAT4663523
Duration: 01/12/2023 – 30/11/2026
https://www.fwf.ac.at/en/research-radar/10.55776/PAT4663523
Artificial intelligence for diagnostics of ALT-positive cancer (AI4CAN)
CCRI responsible Principal Investigator: Sabine Taschner-Mandl
Grant from the Vienna Science and Technology Fund (WWTF), NEXT 2022, ID – NXT22-009
Duration: 01/09/2023 – 28/02/2025
https://www.wwtf.at/funding/
Disease-associated variants at ARID5B
CCRI responsible Principal Investigator: Davide Seruggia
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P36302
Duration: 01/09/2023 – 31/08/2026
https://www.fwf.ac.at/en/research-radar/10.55776/P36302
RiboPOP
CCRI responsible Project Lead: Irinka Castanon (Kaan Boztug group)
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P36334
Duration 01/02/2023 – 31/01/2026
https://ccri.at/
Lost in translation
CCRI responsible Principal Investigator: Kaan Boztug
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P36548
Duration 01/02/2023 – 31/01/2026
https://ccri.at/
Development of Hsp90 C-terminal domain inhibitors for the treatment of pediatric sarcomas
CCRI responsible Head of Facility and Coordinator: Martin Distel
Grant from the Austria’s Agency for Education and Internationalisation (OEAD), ID – SI 29/2023
Duration: 01/01/2023 – 31/12/2024
https://oead.at/en/
Iterative programming of blood cells (ML2Cell)
CCRI responsible Principal Investigator: Florian Halbritter
Grant from the Austrian Science Fund (FWF), TAI-1000 Ideas Program, DOI: 10.55776/TAI732
Duration: 01/01/2023 – 31/07/2024
https://www.fwf.ac.at/en/news-and-media-relations/
Harnessing vulnerabilities at SAGA in MYC-driven cancer
CCRI responsible Principal Investigator: Davide Seruggia
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P36069
Duration: 01/01/2023 – 31/12/2025
https://www.fwf.ac.at/en/research-radar/10.55776/P36069
Targeting Tumor Metabolism (TATUM)
CCRI responsible Project Lead: Artem Kalinichenko (Kaan Boztug group)
Grant from the Austrian Science Fund (FWF), TAI-1000 Ideas Program, DOI: 10.55776/TAI815
Duration: 01/11/2022 – 31/10/2024
https://www.fwf.ac.at/en/news-and-media-relations/
Linking ex-vivo chemosensitivity, treatment and pathway activations for a deeper understanding of pediatric AML (ExTrAct-AML)
CCRI responsible Principal Investigator and Coordinator: Kaan Boztug
Additional project partners: Giulio Superti-Furga (CeMM) and Michael Dworzak (CCRI)
Grant from the Austrian Science Fund (FWF), Programme Clinical Research, DOI: 10.55776/KLI1056
Duration: 01/10/2022 – 30/09/2024
https://www.fwf.ac.at/en/research-radar/10.55776/KLI1056
Regulating CAR T cells with a safe and naturally occurring drug
CCRI responsible researcher: Elise Sylvander (supervisor: Manfred Lehner)
Grant from the Austria Academy of Sciences (ÖAW), DOC fellowship, ID – 26323
Duration: 01/07/2022 – 01/07/2024
https://ccri.at/
Exploration of lung metastases in pediatric cancer through single-cell analysis and 3d modelling (MetLung)
CCRI responsible Principal Investigator and Coordinator: Heinrich Kovar
Additional CCRI Collaborator: Florian Halbritter
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P35353
Duration: 02/05/2022 – 01/05/2025
https://www.fwf.ac.at/en/research-radar/10.55776/P35353
MAPMET – Mapping metastatic cancer by multi-modal imaging
CCRI responsible Principal Investigator: Sabine Taschner-Mandl
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P35841
Duration: 01/05/2022 – 30/04/2026
https://www.fwf.ac.at/en/research-radar/10.55776/P35841
Cracking the ribosome code of drug resistance in sarcomas
CCRI responsible Principal Investigator: Eleni Tomazou
Grant from the Austrian Science Fund (FWF), TAI-1000 Ideas Program, DOI: 10.55776/TAI592
Duration: 01/01/2022 to 31/12/2024
https://www.fwf.ac.at/en/news-and-media-relations/
Interplay of fusion genes and cellular context in sarcoma
CCRI responsible Principal Investigator: Eleni Tomazou
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P34958
Duration: 01/10/2021 – 31/03/2025
https://www.fwf.ac.at/en/research-radar/10.55776/P34958
Validation of a liquid biopsy based molecular diagnostic toolkit for pediatric sarcomas
CCRI responsible Principal Investigator: Eleni Tomazou
Grant from the Vienna Science and Technology Fund (WWTF), Life Sciences 2020, ID – LS20-045
Duration: 01/09/2021 – 31/08/2025
https://www.wwtf.at/funding/programmes/ls/LS20-045/
How do leukemic cells escape natural killer cell-mediated surveillance?
CCRI responsible researcher: Michelle Buri (supervisor: Eva König)
Grant from the Austria Academy of Sciences (ÖAW), DOC fellowship, ID – 25905
Duration: 01/08/2021 – 01/08/2024
https://stipendien.oeaw.ac.at/stipendien/doc/doc-gefoerderte-personen
Establishing light-mediated clonal cancer models to investigate tumor initiation
CCRI responsible researcher: Adam Varady (supervisor: Martin Distel)
Grant from the Austria Academy of Sciences (ÖAW), DOC fellowship, ID – 25931
Duration: 01/08/2021 – 01/02/2024
https://stipendien.oeaw.ac.at/stipendien/doc/doc-gefoerderte-personen
Characterization of bacterial-fungal interactions: a basis for discovery of microbial markers (BacFun)
CCRI responsible Principal Investigator: Thomas Lion
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P34152
Duration: 01/08/2021 – 31/07/2024
https://www.fwf.ac.at/en/research-radar/10.55776/P34152
Identification of a key molecular coordinator of the exocytosis machinery and cytoskeletal dynamics essential for human lymphocyte cytotoxicity
CCRI responsible Principal Investigator: Kaan Boztug
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P34834
Duration 01/07/2021 – 30/06/2024
https://www.fwf.ac.at/en/research-radar/10.55776/P34834
EWS-FLI1 fluctuation in Ewing sarcome
CCRI responsible Principal Investigator: Heinrich Kovar
Grant from the Austrian Science Fund (FWF), Stand-Alone Project, DOI: 10.55776/P34341
Duration 01/04/2021 – 31/03/2025
https://www.fwf.ac.at/de/news-presse/news/nachricht/nid/20211221-2710
Decontamination of sensitive materials using cold atmospheric plasma technology
CCRI responsible Principal Investigator: Thomas Lion
Grant from the Austrian Science Fund (FWF), CEUS, DOI: 10.55776/I5293
Duration: 01/04/2021 – 30/09/2024
https://www.fwf.ac.at/en/
Automated minimal residual disease assessment in childhood acute myeloid leukemia
CCRI responsible researcher: Margarita Maurer-Granofszky (supervisor: Michael Dworzak)
Grant from the Vienna Business Agency, From Science to Products 2019, ID – 2841342
Duration: 15/03/2020 – 30/09/2024
https://viennabusinessagency.at/
CD Laboratory for “Next generation CAR-T cells”
Head of CD Laboratory and Coordinator: Manfred Lehner
Grant from the Christian Doppler Association, Christian Doppler Lab, ID – 345
Duration: 01/11/2019 to 31/10/2026
https://christian-doppler.ccri.at/
Ultra-high-risk pediatric cancer – combinatorial drivers and therapeutic targets for precision medicine
CCRI responsible Principal Investigator and Coordinator: Sabine Taschner-Mandl
Additional CCRI Collaborators: Ruth Ladenstein and Martin Distel
Grant from the Vienna Science and Technology Fund (WWTF), Life Sciences 2018, ID – LS18-111
Duration: 01/03/2019 – 28/02/2024
https://www.wwtf.at/funding/programmes/ls/LS18-111/
Internationally Funded Projects
A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis (MONALISA)
CCRI responsible Principal Investigator and Scientific Coordinator: Sabine Taschner-Mandl
Coordinator: SIOPE, Belgium
Grant from the European Commission, Horizon Europe, ID – 101137028
Duration: 01/01/2024 – 31/12/2028
https://cordis.europa.eu/project/id/101137028
European Reference Network on Paediatric Oncology Y7-Y10 (ERN-PaedCan)
CCRI responsible Principal Investigator and Coordinator: Ruth Ladenstein
Grant from the European Union, EU4Health Work Programme, ID – 101155946
Duration: 01/10/2023 – 30/09/2027
https://paedcan.ern-net.eu/
Developmentally programmed pediatric sarcomas: a versatile platform for drug discovery and molecular precision medicine (SARCOMAkids)
CCRI responsible Principal Investigator: Eleni Tomazou
Grant from the European Commission, European Research Council Consolidator Grant (ERC-CoG), ID – 101087883
Duration: 01/09/2023 – 31/08/2028
https://cordis.europa.eu/project/id/101087883
International Study for Treatment of Childhood Relapsed ALL 2020 (IntReALL 2020)
CCRI responsible Principal Investigator: Ruth Ladenstein
Coordinator: Arend von Stackelberg (Charité, Germany)
Additional CCRI-linked Collaborators: Andishe Attarbaschi (SAK)
Grant from the European Commission, Horizon Europe, ID – 101104582
Duration: 01/05/2023 – 30/04/2028
https://cordis.europa.eu/project/id/101104582
Molecular dissection of the role of an RNA-binding protein in human immune homeostasis
CCRI responsible researcher: Cheryl van de Wetering (Supervisor: Kaan Boztug)
Grant from the Peter und Traudl Engelhorn-Stiftung
Duration: 01/01/2023 – 31/12/2024
Cancer Survivor Smart Card
CCRI responsible Principal Investigator: Ruth Ladenstein
Coordinator: European Cancer Organisation (Belgium)
Grant from the EU4Health Programme 2021-2027, ID – 101080048
Duration: 01/01/2023 – 31/12/2024
https://www.europeancancer.org/eu-projects/impact/smartcare
High-resolution dissection of non-coding determinants of disease (B-ALLeles)
CCRI responsible researcher: Ana Patricia Kutschat (Supervisor: Davide Seruggia)
Grant from the European Union, HE- Marie Sklodowska-Curie Action Postdoctoral Fellowship, ID – 101061151
Duration: 01/11/2022 – 31/10/2024
https://cordis.europa.eu/project/id/101061151
Towards an UNIque approach for artificial intelligence data-driven solutions to fight Childhood cAncer FOR Europe (UNICA4EU)
CCRI responsible Principal Investigator: Ruth Ladenstein
Coordinator: SIOPE, Belgium
Grant from the European Union, Pilot Projects and Preparatory Actions (PPPA), ID – LC-01815952 / 101052609
Duration: 01/07/2022 to 29/02/2024
https://unica4.eu/
Functional Interrogation of Non-coding DNA Sequences in leukemia development and drug resistance (FIND-seq)
CCRI responsible Principal Investigator: Davide Seruggia
Grant from the European Union, H2020 ERC Starting Grant, ID – 947803
Duration: 01/03/2021 – 28/02/2026
https://cordis.europa.eu/project/id/947803
European Rare Disease Research Coordination and Support Action (ERICA)
CCRI responsible Principal Investigator: Ruth Ladenstein
Coordinator: Alberto Pereira (Leiden University Medical Center, the Netherlands)
Grant from the European Union, H2020, ID – 964908
Duration: 01/03/2021 to 28/02/2025
https://erica-rd.eu/
Tracking Ewing sarcoma origin by developmental and trans-species genomics (ORIGIN)
CCRI responsible Principal Investigator and Coordinator: Heinrich Kovar
Additional CCRI Collaborators: Martin Distel and Florian Halbritter
Grant from Alex’s Lemonade Stand Foundation (ALSF), Crazy 8 Initiative Award Program
Duration: 01/03/2021 – 28/02/2025
https://www.alexslemonade.org/project/tracking-ewing-sarcoma-origin-developmental-and-trans-species-genomics
PanCare studies of the scale-up and implementation of the digital Survivorship Passport to improve people-centred care for childhood cancer survivors (PanCareSurPass)
CCRI responsible Principal Investigator: Ruth Ladenstein
Coordinator: Desiree Grabow (Universitätsmedizin Mainz, Germany)
Grant from the European Union, H2020, ID – 899999
Duration: 01/03/2021 to 28/02/2025
https://www.pancaresurpass.eu/
Validation of Actionable Genomic Aberrations in a Paediatric Oncology Network for Doctorate students (VAGABOND)
CCRI responsible Principal Investigator: Heinrich Kovar
Coordinator: Jan Molenaar (Prinses Máxima Centrum, the Netherlands)
Grant from the European Union, H2020 – MSCA Innovative Training Networks, ID – 956285
Duration: 01/12/2020 – 30/11/2024
https://vagabondnetwork.com/
Integrated and standardized NGS workflows for Personalised therapy (INSTAND-NGS4P)
CCRI responsible Principal Investigators: Ruth Ladenstein and Kaan Boztug
Coordinator: Kurt Zatloukal (Medical University Graz, Austria)
Grant from the European Union, H2020 – Innovation Procurement, ID – 874719
Duration: 01/01/2020 – 31/05/2025
https://www.instandngs4p.eu/
Charting key molecules and mechanisms of human immune Dysregulation (iDysChart)
CCRI responsible Principal Investigator and Coordinator: Kaan Boztug
Grant from the European Commission, European Research Council Consolidator Grant (ERC-CoG), ID – 820074
Duration: 01/06/2019 – 31/05/2025
https://cordis.europa.eu/project/id/820074
Childhood Leukemia: Overcoming distance between South America and Europe Regions (CLOSER)
CCRI responsible Principal Investigator: Sabine Strehl
Coordinator: Mireia Camos (Hospital Sant Joan de Déu de Barcelona, Spain)
Grant from the European Union, H2020, ID – 825749
Duration: 01/01/2019 – 31/03/2024
https://closerleukemia.eu/
European Joint Programme on Rare Diseases (EJP RD)
CCRI responsible Principal Investigator: Ruth Ladenstein
Coordinator: Daria Julkowska (Inserm, France)
Grant from the European Union, H2020, ID – 825575
Duration: 01/01/2019 – 31/08/2024
https://www.ejprarediseases.org/