This year’s 1000 ideas program of FWF promotes another two of St. Anna CCRI’s “completely new, daring or particularly original research ideas that lie outside the current scientific understanding”. Florian Halbritter’s new approach aims to integrate machine learning directly into the experimental design and execution of manufacturing specific cell types from stem cells – with the ultimate goal to reprogram even cancer cells. Artem Kalinichenko, who was also awarded a 1000 ideas grant, is targeting abnormal tumor metabolism by identifying cancer-derived metabolites, drugs and drug metabolites that trigger an immune reaction, which could later be exploited for immunotherapy.